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. 1987 Mar 1;242(2):607-10.
doi: 10.1042/bj2420607.

Investigation of the role of Ca2+ and calmodulin in the regulation of platelet guanylate cyclase activity

S Mac Neil

Investigation of the role of Ca2+ and calmodulin in the regulation of platelet guanylate cyclase activity

S Mac Neil. Biochem J. .

Abstract

Both soluble and particulate forms of human platelet guanylate cyclase were found to be sensitive to sub-micromolar concentrations of free Ca2+; soluble enzyme activity increased as Ca2+ was increased from 10 nM to 1 microM; particulate enzyme activity showed a biphasic response to Ca2+, with maximal enzyme activity between 1 and 10 nM free Ca2+ and inhibition occurring at higher Ca2+ concentrations. Neither Ca2+-sensitivity appeared to be calmodulin-dependent.

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