Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Aug 29;15(9):273.
doi: 10.3390/md15090273.

Marine Pharmacology in 2012-2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Alejandro M S Mayer  1 , Abimael D Rodríguez  2 , Orazio Taglialatela-Scafati  3 , Nobuhiro Fusetani  4
Affiliations
Review

Marine Pharmacology in 2012-2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Alejandro M S Mayer et al. Mar Drugs. .

Abstract

The peer-reviewed marine pharmacology literature from 2012 to 2013 was systematically reviewed, consistent with the 1998-2011 reviews of this series. Marine pharmacology research from 2012 to 2013, conducted by scientists from 42 countries in addition to the United States, reported findings on the preclinical pharmacology of 257 marine compounds. The preclinical pharmacology of compounds isolated from marine organisms revealed antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral and anthelmitic pharmacological activities for 113 marine natural products. In addition, 75 marine compounds were reported to have antidiabetic and anti-inflammatory activities and affect the immune and nervous system. Finally, 69 marine compounds were shown to display miscellaneous mechanisms of action which could contribute to novel pharmacological classes. Thus, in 2012-2013, the preclinical marine natural product pharmacology pipeline provided novel pharmacology and lead compounds to the clinical marine pharmaceutical pipeline, and contributed significantly to potentially novel therapeutic approaches to several global disease categories.

Keywords: chemical; drug; marine; metabolite; natural product; pharmaceutical; pharmacology; pipeline; review; toxicology.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 1
Figure 1
Marine pharmacology in 2012–2013: marine compounds with antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities.
Figure 2
Figure 2
Marine pharmacology in 2012–2013: marine compounds with antidiabetic and anti-inflammatory activity; and affecting the immune and nervous system.
Figure 2
Figure 2
Marine pharmacology in 2012–2013: marine compounds with antidiabetic and anti-inflammatory activity; and affecting the immune and nervous system.
Figure 2
Figure 2
Marine pharmacology in 2012–2013: marine compounds with antidiabetic and anti-inflammatory activity; and affecting the immune and nervous system.
Figure 2
Figure 2
Marine pharmacology in 2012–2013: marine compounds with antidiabetic and anti-inflammatory activity; and affecting the immune and nervous system.
Figure 2
Figure 2
Marine pharmacology in 2012–2013: marine compounds with antidiabetic and anti-inflammatory activity; and affecting the immune and nervous system.
Figure 2
Figure 2
Marine pharmacology in 2012–2013: marine compounds with antidiabetic and anti-inflammatory activity; and affecting the immune and nervous system.
Figure 3
Figure 3
Marine pharmacology in 2012–2013: marine compounds with miscellaneous mechanisms of action.
Figure 3
Figure 3
Marine pharmacology in 2012–2013: marine compounds with miscellaneous mechanisms of action.
Figure 3
Figure 3
Marine pharmacology in 2012–2013: marine compounds with miscellaneous mechanisms of action.
Figure 3
Figure 3
Marine pharmacology in 2012–2013: marine compounds with miscellaneous mechanisms of action.
Figure 3
Figure 3
Marine pharmacology in 2012–2013: marine compounds with miscellaneous mechanisms of action.
Figure 3
Figure 3
Marine pharmacology in 2012–2013: marine compounds with miscellaneous mechanisms of action.
Figure 3
Figure 3
Marine pharmacology in 2012–2013: marine compounds with miscellaneous mechanisms of action.
See this image and copyright information in PMC

References

    1. Mayer A.M.S., Lehmann V.K.B. Marine pharmacology in 1998: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, anthelmintic, antiplatelet, antiprotozoal, and antiviral activities;with actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action. Pharmacologist. 2000;42:62–69.
    1. Mayer A.M.S., Hamann M.T. Marine pharmacology in 1999: Compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, anthelmintic, anti-inflammatory, antiplatelet, antiprotozoal and antiviral activities; affecting the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. 2002;132:315–339. - PubMed
    1. Mayer A.M.S., Hamann M.T. Marine pharmacology in 2000: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action. Mar. Biotechnol. 2004;6:37–52. - PMC - PubMed
    1. Mayer A.M.S., Hamann M.T. Marine pharmacology in 2001–2002: Marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2005;140:265–286. - PMC - PubMed
    1. Mayer A.M.S., Rodriguez A.D., Berlinck R.G., Hamann M.T. Marine pharmacology in 2003-4: Marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2007;145:553–581. - PMC - PubMed

MeSH terms