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Review
. 2017 Oct 18;34(10):1193-1202.
doi: 10.1039/c7np00025a.

The importance of asking "how and why?" in natural product structure elucidation

Patrick D Brown  1 , Andrew L Lawrence
Affiliations
Review

The importance of asking "how and why?" in natural product structure elucidation

Patrick D Brown et al. Nat Prod Rep. .

Abstract

Covering: up to 2017This review highlights why careful consideration of the biosynthetic origin (the how) and the biological function (the why) of a natural product can be so useful during the determination of its structure. Recent examples of structural reassignments inspired by biosynthetic and functional insights will be presented. This review will demonstrate the importance of viewing the origin, structure and function of a natural product as intertwined threads of a single story, best viewed as a whole rather than as discrete topics.

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