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Meta-Analysis
. 2017 Aug 29;18(1):95.
doi: 10.1186/s12881-017-0458-8.

Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis

Lina Yang  1   2 , Lan Wu  1 , Yi Fan  2 , Jianfei Ma  3
Affiliations
Meta-Analysis

Vitamin D receptor gene polymorphisms in association with diabetic nephropathy: a systematic review and meta-analysis

Lina Yang et al. BMC Med Genet. .

Abstract

Background: A large amount of researches have demonstrated that vitamin D receptor (VDR) gene polymorphisms are associated with diabetic nephropathy (DN) risk in diabetes mellitus (DM) patients. Nevertheless, the results are inconclusive and inconsistent.

Methods: We screened PubMed, Embase, Chinese National Knowledge Infrastructure and Chinese Wanfang databases for those relevant studies updated in May 2016.

Results: 7 studies involving 2564 subjects were recruited. We evaluated the genotypic and allelic differences between DN patients and DM controls. Overall analysis showed that no significant association was found among the ApaI, BsmI, FokI,TaqI gene polymorphisms and DN susceptibility in diabetic patients (all P values > 0.05). In the stratified analysis, TT genotype was related to DN susceptibility in Asians (TT vs Tt + tt: OR =2.21, 95% CI: 1.05-4.67, p = 0.04). The sensitivity analysis showed that the results in overall populations, Caucasians and Asians were dependable.

Conclusions: No significant association was found among the ApaI, BsmI, FokI, TaqI polymorphisms and DN risk in overall populations, the TaqI variants might related to DN susceptibility in Asians. Further researches are required to testify our meta-analysis.

Keywords: Diabetic nephropathy; Gene polymorphisms; Meta-analysis; Vitamin D receptor.

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The authors declare that no competing interests exist.

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Figures

Fig. 1
Fig. 1
Flow diagram of included and excluded studies
Fig. 2
Fig. 2
Association of VDR BsmI gene polymorphism(B vs b)with DN susceptibility in overall populations
Fig. 3
Fig. 3
Association of VDR FokI gene polymorphism(F vs f) with DN susceptibility in overall populations
Fig. 4
Fig. 4
Association of VDR TaqI gene polymorphism(T vs t) with DN susceptibility in overall populations
Fig. 5
Fig. 5
Association of VDR ApaI gene polymorphism(A vs a) with DN susceptibility in overall populations
See this image and copyright information in PMC

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