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Review
. 2017:2017:8160148.
doi: 10.1155/2017/8160148. Epub 2017 Aug 9.

Potential Biomarkers for NSAID-Exacerbated Respiratory Disease

Hanki Park  1 , Youngwoo Choi  2 , Chang-Gyu Jung  2 , Hae-Sim Park  2
Affiliations
Review

Potential Biomarkers for NSAID-Exacerbated Respiratory Disease

Hanki Park et al. Mediators Inflamm. 2017.

Abstract

Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available. Recent studies have reported various biomarkers of phenotype, diagnosis, and prognosis. In this review, we summarized the known potential biomarkers of NERD that are distinct from those of aspirin-tolerant asthma. We also provided an overview of the different NERD subgroups.

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References

    1. Samter M., Beers R. F. Intolerance to aspirin: clinical studies and consideration of its pathogenesis. Annals of Internal Medicine. 1968;68(5):975–983. - PubMed
    1. Rajan J. P., Wineinger N. E., Stevenson D. D., White A. A. Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature. Journal of Allergy and Clinical Immunology. 2015;135(3):676.e1–681.e1. doi: 10.1016/j.jaci.2014.08.020. - DOI - PubMed
    1. Lee J. H., Haselkorn T., Borish L., Rasouliyan L., Chipps B. E., Wenzel S. E. Risk factors associated with persistent airflow limitation in severe or difficult-to-treat asthma: insights from the TENOR study. Chest Journal. 2007;132(6):1882–1889. doi: 10.1378/chest.07-0713. - DOI - PubMed
    1. E. S. Group. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Respiratory Journal. 2003;22(3):470–477. - PubMed
    1. Lin D. C., Chandra R. K., Tan B. K., et al. Association between severity of asthma and degree of chronic rhinosinusitis. American Journal of Rhinology & Allergy. 2011;25(4):p. 205. doi: 10.2500/ajra.2011.25.3613. - DOI - PMC - PubMed

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