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Review
. 2017:2017:8160148.
doi: 10.1155/2017/8160148. Epub 2017 Aug 9.

Potential Biomarkers for NSAID-Exacerbated Respiratory Disease

Hanki Park  1 , Youngwoo Choi  2 , Chang-Gyu Jung  2 , Hae-Sim Park  2
Affiliations
Review

Potential Biomarkers for NSAID-Exacerbated Respiratory Disease

Hanki Park et al. Mediators Inflamm. 2017.

Abstract

Asthma is a common chronic disease with several variant phenotypes and endotypes. NSAID-exacerbated respiratory disease (NERD) is one such endotype characterized by asthma, chronic rhinosinusitis (CRS) with nasal polyps, and hypersensitivity to aspirin/cyclooxygenase-1 inhibitors. NERD is more associated with severe asthma than other asthma phenotypes. Regarding diagnosis, aspirin challenge tests via the oral or bronchial route are a standard diagnostic method; reliable in vitro diagnostic tests are not available. Recent studies have reported various biomarkers of phenotype, diagnosis, and prognosis. In this review, we summarized the known potential biomarkers of NERD that are distinct from those of aspirin-tolerant asthma. We also provided an overview of the different NERD subgroups.

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