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. 2017 Apr-Jun;10(2):101-105.
doi: 10.4103/JCAS.JCAS_115_16.

Assessment of the Efficacy and Safety of Hyaluronic Acid Gel Injection in the Restoration of Fullness of the Upper Lips

Taraneh Yazdanparast  1   2 , Aniseh Samadi  1 , Hournaz Hasanzadeh  1 , Saman Ahmad Nasrollahi  1 , Alireza Firooz  1 , Mansour Nassiri Kashani  1
Affiliations

Assessment of the Efficacy and Safety of Hyaluronic Acid Gel Injection in the Restoration of Fullness of the Upper Lips

Taraneh Yazdanparast et al. J Cutan Aesthet Surg. 2017 Apr-Jun.

Abstract

Background and aim: Lips have a significant role in face aesthetic perception, and lip augmentation is one of the most commonly requested aesthetic procedures. Non-permanent dermal fillers, such as hyaluronic acid (HA), are used for augmenting the lips. This article presents the results of Phase II, before - after designed study, assessing the safety and efficacy of a soft tissue HA filler, for upper lip augmentation.

Materials and methods: Investigators treated 10 healthy adult women 28-45 years old, using a single injection of Hyamax Kiss soft tissue HA filler (a product from Hyamed Laboratories, Switzerland) for upper lip augmentation. The primary efficacy endpoint was an increase in lip fullness at least one grade on Medicis Lip Fullness Scale at 2, 12 and 24 weeks post-treatment. Furthermore, the effectiveness and durability of filler were assessed using a 5-point Investigator's Global Assessment (IGA). Adverse events and volunteers' satisfaction were reported using visual analog scale.

Results: Response to treatment (as defined above) after 2, 12 and 24 weeks were observed in 80%, 70% and 80% of patients, respectively. No statistical difference was found in response to treatment rate between follow-up visits (P = 0.83). The mean value of IGA score in weeks 2, 12 and 24 were 3.4 ± 0.96, 3.3 ± 0.67 and 3.3 ± 0.67, respectively. The study subjects were almost all satisfied with their lip improvement. Reported adverse effects were temporary and mostly mild in severity.

Conclusion: Soft tissue HA filler tested in this study was well tolerated, efficient and durable when used for upper lip augmentation.

Keywords: Hyaluronic acid; lip augmentation; lip filler.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Percent of subjects with improved Medicis Lip Fullness Scale from baseline based on blind evaluator assessments
Figure 2
Figure 2
Representative photographs of volunteers' lips (a and e) before treatment, (b and f) 2 weeks after treatment, (c and g) 12 weeks after treatment and (d and h) 24 weeks after treatment
Figure 3
Figure 3
Dermatologist opinion about the effectiveness and durability of filler using 5-point Investigator's Global Assessment Scale. Mean value in 10 volunteers in 2, 12 and 24 weeks after treatment with hyaluronic acid dermal filler
See this image and copyright information in PMC

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