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. 2017 Aug 14;23(30):5634-5644.
doi: 10.3748/wjg.v23.i30.5634.

Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms

Cameron I Wells  1 , Gregory O'Grady  1 , Ian P Bissett  1
Affiliations

Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms

Cameron I Wells et al. World J Gastroenterol. .

Abstract

Aim: To critically review the literature addressing the definition, epidemiology, aetiology and pathophysiology of acute colonic pseudo-obstruction (ACPO).

Methods: A systematic search was performed to identify articles investigating the aetiology and pathophysiology of ACPO. A narrative synthesis of the evidence was undertaken.

Results: No consistent approach to the definition or reporting of ACPO has been developed, which has led to overlapping investigation with other conditions. A vast array of risk factors has been identified, supporting a multifactorial aetiology. The pathophysiological mechanisms remain unclear, but are likely related to altered autonomic regulation of colonic motility, in the setting of other predisposing factors.

Conclusion: Future research should aim to establish a clear and consistent definition of ACPO, and elucidate the pathophysiological mechanisms leading to altered colonic function. An improved understanding of the aetiology of ACPO may facilitate the development of targeted strategies for its prevention and treatment.

Keywords: Acute colonic pseudo-obstruction; Acute colonic pseudoobstruction; Colonic; Intestinal; Ogilvie’s syndrome; Pseudo obstruction; Pseudo-Obstruction.

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Conflict of interest statement

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Pathophysiological factors that have been implicated in the development of acute colonic pseudo-obstruction. ICC: Interstitial cells of Cajal; ENS: Enteric nervous system.
See this image and copyright information in PMC

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