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Review
. 2017 Jul;12(7):1044-1047.
doi: 10.4103/1673-5374.211177.

Spinal cord injury drives chronic brain changes

Ignacio Jure  1 , Florencia Labombarda  1   2
Affiliations
Review

Spinal cord injury drives chronic brain changes

Ignacio Jure et al. Neural Regen Res. 2017 Jul.

Abstract

Only a few studies have considered changes in brain structures other than sensory and motor cortex after spinal cord injury, although cognitive impairments have been reported in these patients. Spinal cord injury results in chronic brain neuroinflammation with consequent neurodegeneration and cognitive decline in rodents. Regarding the hippocampus, neurogenesis is reduced and reactive gliosis increased. These long-term abnormalities could explain behavioral impairments exhibited in humans patients suffering from spinal cord trauma.

Keywords: brain neurodegeneration; neuroinflammation; spinal cord injury.

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Conflict of interest statement

Conflicts of interest: None declared.

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