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Case Reports
. 2017 Jul 31;2017(7):rjw138.
doi: 10.1093/jscr/rjw138. eCollection 2017 Jul.

Neurofibromatosis type 1 and male breast cancer: emerging risk factor?

Nolan Mann  1 , Truong Ma  1 , Arthur Dalton  1
Affiliations
Case Reports

Neurofibromatosis type 1 and male breast cancer: emerging risk factor?

Nolan Mann et al. J Surg Case Rep. .

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by the appearance of cafe au lait spots, neurofibromas and Lisch nodules. There is an established link between NF1 and the development of breast cancer in women; however, due to the rarity of both NF1 and male breast cancer, the same link has yet to be elucidated in men. The concurrent presentation of NF1 and male breast cancer is a very rare phenomenon with only a handful of case descriptions in the literature. To the best of our knowledge, there have only been four other reported cases of NF1 and male breast cancer before ours. We present one such case of a 56-year-old male with a four generation history of NF1 and a personal history of NF1 who presented with invasive ductal carcinoma of the right breast.

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Figures

Figure 1:
Figure 1:
Right chest wall neurofibroma. Breast cancer is superior to the nipple.
Figure 2:
Figure 2:
Preoperative staging CT scan. Chest wall mass noted to be 6.9 cm × 2 cm.
Figure 3:
Figure 3:
Post chemotherapy PET/CT scan. The breast mass decreased in size, with no mediastinal or hilar lymphadenopathy.
See this image and copyright information in PMC

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