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. 2017 Aug;10(4):479-486.
doi: 10.1093/ckj/sfx058. Epub 2017 Jul 12.

Prevalence and determinants of microalbuminuria in children suffering from sickle cell anemia in steady state

Michel N Aloni  1 , Jean-Louis L Mabidi  1 , René M Ngiyulu  1 , Pépé M Ekulu  1 , Fiston I Mbutiwi  2 , Jean Robert Makulo  2 , Ernest K Sumaili  2 , Jean Lambert Gini-Ehungu  1 , Célestin N Nsibu  3 , Nazaire M Nseka  2 , François B Lepira  2
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Prevalence and determinants of microalbuminuria in children suffering from sickle cell anemia in steady state

Michel N Aloni et al. Clin Kidney J. 2017 Aug.

Abstract

Background: Sickle cell anemia (SCA) is considered a major risk factor for renal complications. The main goal of this study was to determine the frequency of macroalbuminuria and microalbuminuria in Congolese children <18 years of age suffering from Sickle cell anemia and to identify associated factors.

Methods: The cross-sectional study was completed in 150 hemoglobin-SS children (77 boys and 73 girls). Microalbuminuria was defined by a urine albumin:creatinine ratio of 30-299 mg/g.

Results: The mean age of this group was 8.8 ± 4.3 years (range 2-18). Microalbuminuria was found in 27 children (18%). In multivariate logistic regression, only age emerged as a determinant of microalbuminuria odds ratio 1.11 (95% confidence interval 1.00-1.22); P = 0.042].

Conclusions: In our series, only age was a major determinant of the occurrence of microalbuminuria. These results confirm the need for early screening of microalbuminuria in Congolese children suffering from Sickle cell anemia in a context where access to renal and bone marrow transplant is nonexistent.

Keywords: Africa; children; microalbuminuria; risk factors; sickle cell anemia.

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Figures

Fig. 1
Fig. 1
Relationship between logarithm of albumin:creatinine ratio and age.
Fig. 2
Fig. 2
Relationship between eGFR and age.
Fig. 3
Fig. 3
Log10 of microalbuminuria by age.
See this image and copyright information in PMC

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References

    1. Quinn CT. Sickle cell disease in childhood: from newborn screening through transition to adult medical care. Pediatr Clin North Am 2013; 60: 1363–1381 - PMC - PubMed
    1. Powars DR, Chan LS, Hiti A. et al. Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients. Medicine (Baltimore) 2005; 84: 363–376 - PubMed
    1. Powars DR, Elliott-Mills DD, Chan L. et al. Chronic renal failure in sickle cell disease: risk factors, clinical course, and mortality. Ann Intern Med 1991; 115: 614–620 - PubMed
    1. Scheinman JI. Sickle cell disease and the kidney. Nat Clin Pract Nephrol 2009; 5: 78–88 - PubMed
    1. Guasch A, Navarrete J, Nass K. et al. Glomerular involvement in adults with sickle cell hemoglobinopathies: prevalence and clinical correlates of progressive renal failure. J Am Soc Nephrol 2006; 17: 2228–2235 - PubMed

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