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. 2017 Aug;10(4):524-531.
doi: 10.1093/ckj/sfx006. Epub 2017 Mar 27.

High-density lipoprotein particle pattern and overall lipid responses to a short-term moderate-intensity aerobic exercise training intervention in patients with chronic kidney disease

Emily M Miele  1 , Samuel A E Headley  1 , Michael Germain  2 , Jyovani Joubert  1 , Sarah Herrick  1 , Charles Milch  1 , Elizabeth Evans  1 , Allen Cornelius  3 , Britton Brewer  1 , Beth Taylor  4 , Richard J Wood  1
Affiliations

High-density lipoprotein particle pattern and overall lipid responses to a short-term moderate-intensity aerobic exercise training intervention in patients with chronic kidney disease

Emily M Miele et al. Clin Kidney J. 2017 Aug.

Abstract

Background: Chronic kidney disease (CKD) is associated with abnormal lipid profiles and altered high-density lipoprotein (HDL) particle size patterns. Lower levels of the larger, cardioprotective HDL particles found in CKD may play a role in the increased risk for cardiovascular disease in these patients. The current study was designed to assess the effects of short-term moderate-intensity aerobic exercise training on the HDL particle pattern and overall lipid profiles in stage 3 CKD patients.

Methods: Forty-six men and women with stage 3 CKD were randomized to either exercise (EX, n = 25) or control (CON, n = 21). Those in the EX group completed 16 weeks of supervised moderate-intensity aerobic exercise three times per week. Serum total cholesterol, HDL cholesterol (HDL-C), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), HDL particle size, estimated glomerular filtration rate (eGFR), body composition and peak oxygen uptake (VO2peak) were assessed at baseline and week 16.

Results: The rate of compliance in the EX group was 97 ± 7.2%. No change was observed in eGFR over time in either group. There was an 8.2% improvement in VO2peak in the EX group (P = 0.05), while VO2peak decreased in the CON group. HDL-C, TGs, HDL particle size and body composition remained unchanged in both groups. A trend was found for lower total cholesterol (TC) (P = 0.051) and LDL-C (P = 0.07) in the CON group.

Conclusion: Our findings indicate that a short-term aerobic exercise training intervention in stage 3 CKD patients does not induce changes in HDL particle size or favorable lipid profile modifications.

Keywords: HDL particles; aerobic exercise; chronic kidney disease; lipids.

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Figures

Fig. 1
Fig. 1
Response of HDL particle size to 16 weeks of aerobic exercise in stage 3 CKD patients.
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