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Comment
. 2017 Aug 30;49(9):1288-1289.
doi: 10.1038/ng.3876.

Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

Javad Noorbakhsh  1 , Jeffrey H Chuang  1   2
Affiliations
Comment

Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

Javad Noorbakhsh et al. Nat Genet. .
No abstract available

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Comparison of evolutionary models for TCGA and simulated data. (a) Distribution of R2 values for fits of TCGA allele frequency distribution data to three different models. The numbers on the right side of each plot show the fraction of total tumors in each cancer type with R2 >0.98 (right side of red dashed line). (b) Simulated allele frequency distributions for different generating processes. Thin curves are individual examples of simulated M curves from the neutral (left), purifying selection (middle), and diversifying selection (right) processes, while thick curves are the ideal when no measurement noise exists. See the Supplementary Note and Supplementary Code for details.
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References

    1. William MJ, Werner B, Barnes CP, Graham TA, Sottoriva A. Nat. Genet. 2016;48:238–244. - PMC - PubMed
    1. Cibulskis K, et al. Nat. Biotechnol. 2013;31:213–219. - PMC - PubMed
    1. Gerstung M, et al. Nat. Commun. 2012;3:811. - PubMed

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