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Observational Study
. 2017 Aug 30;17(1):602.
doi: 10.1186/s12885-017-3587-8.

Comprehensive genomic profiling in routine clinical practice leads to a low rate of benefit from genotype-directed therapy

Talal Hilal  1 , Mary Nakazawa  2 , Jacob Hodskins  3 , John L Villano  3 , Aju Mathew  3 , Guarav Goel  4 , Lars Wagner  3 , Susanne M Arnold  3 , Philip DeSimone  3 , Lowell B Anthony  3 , Peter J Hosein  5
Affiliations
Observational Study

Comprehensive genomic profiling in routine clinical practice leads to a low rate of benefit from genotype-directed therapy

Talal Hilal et al. BMC Cancer. .

Abstract

Background: Describe a single-center real-world experience with comprehensive genomic profiling (CGP) to identify genotype directed therapy (GDT) options for patients with malignancies refractory to standard treatment options.

Methods: Patients who had CGP by a CLIA-certified laboratory between November 2012 and December 2015 were included. The medical records were analyzed retrospectively after Institutional Review Board (IRB) approval. The treating oncologist made the decision to obtain the assay to provide potential therapeutic options. The objectives of this study were to determine the proportion of patients who benefited from GDT, and to identify barriers to receiving GDT.

Results: A total of 125 pediatric and adult patients with a histologically confirmed diagnosis of malignancy were included. Among these, 106 samples were from adult patients, and 19 samples were from pediatric patients. The median age was 54 years for adults. The majority had stage IV malignancy (53%) and were pretreated with 2-3 lines of therapy (45%). The median age was 8 years for pediatric patients. The majority had brain tumors (47%) and had received none or 1 line of therapy (58%) when the profiling was requested. A total of 111 (92%) patients had genomic alterations and were candidates for GDT either via on/off-label use or a clinical trial (phase 1 through 3). Fifteen patients (12%) received GDT based on these results including two patients who were referred for genomically matched phase 1 clinical trials. Three patients (2%) derived benefit from their GDT that ranged from 2 to 6 months of stable disease.

Conclusions: CGP revealed potential treatment options in the majority of patients profiled. However, multiple barriers to therapy were identified, and only a small minority of the patients derived benefit from GDT.

Keywords: Cancer therapeutics; Genomics; Genotype-directed therapy; Profiling.

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Conflict of interest statement

Ethics approval and consent to participate

The study was approved by the Institutional Review Board of the University of Kentucky in accordance with the Declaration of Helsinki. Patient consent was waived by the Institutional Review Board of the University of Kentucky as many of the subjects had died and the study represented minimal risk to the remaining patients.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Proportion of samples with alterations by class of molecular pathway
See this image and copyright information in PMC

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