Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Aug 30;7(1):9933.
doi: 10.1038/s41598-017-09851-5.

Nonalcoholic Fatty Liver Disease and Coronary Artery Calcification in a Northern Chinese Population: a Cross Sectional Study

Rina Wu  1 , Feng Hou  2 , Xiaomin Wang  1 , Yong Zhou  3 , Kai Sun  4 , Youxin Wang  5 , Henghui Liu  6 , Jing Wu  6 , Ruiping Zhao  7 , Jiang Hu  8
Affiliations

Nonalcoholic Fatty Liver Disease and Coronary Artery Calcification in a Northern Chinese Population: a Cross Sectional Study

Rina Wu et al. Sci Rep. .

Abstract

Nonalcoholic fatty liver disease (NAFLD) has become an emerging health issue with a high prevalence in general population. The cross-sectional study was performed to investigate the association between NAFLD and coronary artery calcification (CAC) in individuals from northern city of China. A total of 2345 participants aged ≥40 (1035 men and 1310 women) were selected from the Jidong community of Tangshan city. Liver ultrasonography was used to the diagnosis of NAFLD. A 64-slice CT scanner was used to determine coronary artery calcification score (CACS), with CACS > 0 defined to be the presence of CAC. The risk level of coronary heart disease (CHD) was graded by CACS according to the 4 commonly used thresholds in clinical practice (0, 10, 100, and 400 Agatston units). NAFLD was significantly associated with CAC (crude OR: 1.631, 95% CI: 1.295-2.053, adjusted OR: 1.348, 95% CI: 1.030-1.765). The association between NAFLD and increased risk level of CHD (Crude OR: 1.639 95% CI: 1.303-2.063; adjusted OR: 1.359 95% CI: 1.043-1.770) was observed. The associations between NAFLD and CAC or increased risk level of CHD were significant in female but not in male. Our finding further confirmed the association between NAFLD and CAC, especially in Asian population.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Flow Chart of the Enrolled Participants Meet the Requirements.
Figure 2
Figure 2
The prevalence of NAFLD in Jidong Community by sex and Risk Level of CHD.
See this image and copyright information in PMC

References

    1. Mendis, S. et al. Global atlas on cardiovascular disease prevention and control. Geneva World Health Organization (2012).
    1. Greenland P, et al. ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010;56:e50–103. doi: 10.1016/j.jacc.2010.09.001. - DOI - PubMed
    1. Raggi P, et al. Coronary artery calcium to predict all-cause mortality in elderly men and women. J Am Coll Cardiol. 2008;52:17–23. doi: 10.1016/j.jacc.2008.04.004. - DOI - PubMed
    1. Polonsky TS, et al. Coronary artery calcium score and risk classification for coronary heart disease prediction. JAMA. 2010;303:1610–1616. doi: 10.1001/jama.2010.461. - DOI - PMC - PubMed
    1. Budoff MJ, et al. Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients. J Am Coll Cardiol. 2007;49:1860–1870. doi: 10.1016/j.jacc.2006.10.079. - DOI - PubMed

Publication types

MeSH terms