Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Apr 16:31:12-15.
doi: 10.1016/j.ejvssr.2016.03.003. eCollection 2016.

Immediate Catheter Directed Thrombolysis for Thromboembolic Stroke During Carotid Endarterectomy

Affiliations
Case Reports

Immediate Catheter Directed Thrombolysis for Thromboembolic Stroke During Carotid Endarterectomy

E Fletcher et al. EJVES Short Rep. .

Abstract

Background: Carotid artery endarterectomy (CEA) is a common procedure undertaken by vascular surgeons with over 5,000 procedures performed annually worldwide. Published rates of perioperative stroke range from 1.3% to 6.3%.

Case report: A case is presented in which on-table intra-cranial angiography and catheter directed thrombolysis were used for a thromboembolic occlusion of the distal internal carotid artery (ICA) and proximal middle cerebral artery (MCA). An 83-year-old lady developed a dense right hemiparesis while undergoing a CEA under local anaesthetic (LA). Immediate re-exploration of the endarterectomy did not reveal technical error. Intraoperative duplex scanning of the internal carotid artery revealed no detectable diastolic flow. On-table angiogram showed complete occlusion of the distal ICA and proximal MCA. Catheter directed administration of TPA was undertaken. The entire ICA and MCA were completely clear on a completion angiogram. The patient made a full neurological recovery.

Discussion and conclusion: Prompt diagnosis and treatment with intraoperative catheter directed thrombolysis can resolve thromboembolic occlusion of the ICA/MCA. It is argued that performing CEA under LA is useful for immediate recognition of perioperative stroke. Furthermore, the advantage is highlighted of vascular surgeons having both the resources and skillset to perform on-table angiography and thrombolysis.

Keywords: Carotid endarterectomy; Local anaesthetic; Stroke; Thromboembolus; Thrombolysis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Sequential on-table intraoperative angiograms. (A) Initial angiogram demonstrating occlusion of distal ICA. (B) Mid-procedural angiogram after commencing treatment with rt-PA. (C) Isolated ICA angiogram at end of treatment showing newly patent ICA. (D) Completion angiogram at end of treatment.

References

    1. Cina C.S., Clase C.M., Haynes B.R. Refining the indications for carotid endarterectomy in patients with symptomatic carotid stenosis: a systematic review. J Vasc Surg. 1999;30:606–617. - PubMed
    1. Clinical alert: benefit of carotid endarterectomy for patients with high-grade stenosis of the internal carotid artery. National Institute of Neurological Disorders and Stroke and Trauma Division. North American Symptomatic Carotid Endarterectomy Trial (NASCET) investigators. Stroke. 1991;22(6):816–817. - PubMed
    1. Rockman C.B., Jacobowitz G.R., Lamparello P.J., Adelman M.A., Woo D., Schanzer A. Immediate re-exploration for perioperative neurologic event after carotid endarterectomy: is it worthwhile. J Vasc Surg. 2000;32:1062–1070. - PubMed
    1. Huibers A., Calvet D., Kennedy F., Czuriga-Kovacs K.R., Featherstone R.L., Moll F.L. Mechanism of procedural stroke following carotid endarterectomy or carotid artery stenting within the International Carotid Stenting Study (ICSS) randomised trial. Eur J Vasc Endovasc Surg. 2015;50(3):281–288. - PMC - PubMed
    1. Hossman K.A. Viability thresholds and the penumbra of local ischaemia. Ann Neurol. 1994;36:557–565. - PubMed

Publication types

LinkOut - more resources