Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Oct;37(7):727-731.
doi: 10.1007/s10875-017-0437-z. Epub 2017 Aug 31.

Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

Nicolas Degand  1   2 , Justine Dautremer  3 , Benoît Pilmis  4 , Agnès Ferroni  5 , Fanny Lanternier  3 , Julie Bruneau  4 , Olivier Hermine  6 , Stéphane Blanche  7 , Xavier Nassif  5 , Olivier Lortholary  3 , Marc Lecuit  3
Affiliations
Case Reports

Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

Nicolas Degand et al. J Clin Immunol. 2017 Oct.

Abstract

ᅟ: Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.

Purpose: We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.

Methods: 16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.

Results: Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.

Conclusion: In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.

Keywords: Bruton’s disease; Helicobacter bilis; agammaglobulinemia; cholangitis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Clin Microbiol. 1996 Dec;34(12):3165-70 - PubMed
    1. World J Gastroenterol. 2015 Feb 7;21(5):1414-23 - PubMed
    1. J Clin Immunol. 2012 Dec;32(6):1404-8 - PubMed
    1. Lab Anim. 2006 Apr;40(2):115-22 - PubMed
    1. Helicobacter. 2015 Jun;20(3):223-30 - PubMed

Publication types

MeSH terms

Supplementary concepts

LinkOut - more resources