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Case Reports
. 2017 Oct;37(7):727-731.
doi: 10.1007/s10875-017-0437-z. Epub 2017 Aug 31.

Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

Nicolas Degand  1   2 , Justine Dautremer  3 , Benoît Pilmis  4 , Agnès Ferroni  5 , Fanny Lanternier  3 , Julie Bruneau  4 , Olivier Hermine  6 , Stéphane Blanche  7 , Xavier Nassif  5 , Olivier Lortholary  3 , Marc Lecuit  3
Affiliations
Case Reports

Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

Nicolas Degand et al. J Clin Immunol. 2017 Oct.

Abstract

ᅟ: Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.

Purpose: We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.

Methods: 16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.

Results: Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.

Conclusion: In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.

Keywords: Bruton’s disease; Helicobacter bilis; agammaglobulinemia; cholangitis.

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References

    1. J Clin Microbiol. 1996 Dec;34(12):3165-70 - PubMed
    1. World J Gastroenterol. 2015 Feb 7;21(5):1414-23 - PubMed
    1. J Clin Immunol. 2012 Dec;32(6):1404-8 - PubMed
    1. Lab Anim. 2006 Apr;40(2):115-22 - PubMed
    1. Helicobacter. 2015 Jun;20(3):223-30 - PubMed

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