Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2017 Aug 24;22(34):30602.
doi: 10.2807/1560-7917.ES.2017.22.34.30602.

The effectiveness of influenza vaccination in preventing hospitalisations of elderly individuals in two influenza seasons: a multicentre case-control study, Spain, 2013/14 and 2014/15

Angela Domínguez  1   2 , Núria Soldevila  2   1 , Diana Toledo  2   1 , Pere Godoy  3   1   4 , Elena Espejo  5 , Maria Amelia Fernandez  6 , José María Mayoral  7 , Jesús Castilla  1   8 , Mikel Egurrola  9 , Sonia Tamames  10 , Jenaro Astray  11 , María Morales-Suárez-Varela  1   12 ; The Working Group Of The Project Pi/  13
Collaborators, Affiliations
Multicenter Study

The effectiveness of influenza vaccination in preventing hospitalisations of elderly individuals in two influenza seasons: a multicentre case-control study, Spain, 2013/14 and 2014/15

Angela Domínguez et al. Euro Surveill. .

Abstract

Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.

Keywords: effectiveness; elderly; hospitalised cases, hospitalised controls; influenza; matched case–control; vaccination.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Treanor JJ. Influenza Viruses Including Avian Influenza. In: Bennet JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th ed. Philadelphia: Elsevier; 2015. p. 2000-29.
    1. World Health Organization (WHO). Influenza (Seasonal): Fact sheet. Geneva: WHO; Nov 2016. [Accessed 2 Aug 2016]. Available from: http://www.who.int/mediacentre/factsheets/fs211/en/
    1. Foppa IM, Cheng PY, Reynolds SB, Shay DK, Carias C, Bresee JS, et al. Deaths averted by influenza vaccination in the U.S. during the seasons 2005/06 through 2013/14. Vaccine. 2015;33(26):3003-9. 10.1016/j.vaccine.2015.02.042 - DOI - PMC - PubMed
    1. Bonmarin I, Belchior E, Lévy-Bruhl D. Impact of influenza vaccination on mortality in the French elderly population during the 2000-2009 period. Vaccine. 2015;33(9):1099-101. 10.1016/j.vaccine.2015.01.023 - DOI - PubMed
    1. Lang PO, Mendes A, Socquet J, Assir N, Govind S, Aspinall R. Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence. Clin Interv Aging. 2012;7:55-64. 10.2147/CIA.S25215 - DOI - PMC - PubMed

Publication types

MeSH terms

Substances