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Comment
. 2017 Nov;14(11):648-649.
doi: 10.1038/nrclinonc.2017.140. Epub 2017 Aug 31.

Cell signalling: Even kinase-inactive BRAF is oncogenic

David Killock
Comment

Cell signalling: Even kinase-inactive BRAF is oncogenic

David Killock. Nat Rev Clin Oncol. 2017 Nov.
No abstract available

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  • Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.
    Yao Z, Yaeger R, Rodrik-Outmezguine VS, Tao A, Torres NM, Chang MT, Drosten M, Zhao H, Cecchi F, Hembrough T, Michels J, Baumert H, Miles L, Campbell NM, de Stanchina E, Solit DB, Barbacid M, Taylor BS, Rosen N. Yao Z, et al. Nature. 2017 Aug 10;548(7666):234-238. doi: 10.1038/nature23291. Epub 2017 Aug 2. Nature. 2017. PMID: 28783719 Free PMC article.
  • A Braf kinase-inactive mutant induces lung adenocarcinoma.
    Nieto P, Ambrogio C, Esteban-Burgos L, Gómez-López G, Blasco MT, Yao Z, Marais R, Rosen N, Chiarle R, Pisano DG, Barbacid M, Santamaría D. Nieto P, et al. Nature. 2017 Aug 10;548(7666):239-243. doi: 10.1038/nature23297. Epub 2017 Aug 2. Nature. 2017. PMID: 28783725 Free PMC article.

References

    1. Nature. 2017 Aug 10;548(7666):234-238 - PubMed
    1. Nature. 2017 Aug 10;548(7666):239-243 - PubMed

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