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. 1987 Apr;12(4):357-9.
doi: 10.1007/BF00993245.

Changes of cerebral gamma glutamyltransferase activities after treatment with exogenous inducers

J F Ghersi-Egea, A Minn, G Siest

Changes of cerebral gamma glutamyltransferase activities after treatment with exogenous inducers

J F Ghersi-Egea et al. Neurochem Res. 1987 Apr.

Abstract

The activity of gamma-glutamyltransferase localized in isolated brain synaptic membranes- and microvessels-enriched fractions was assayed after treatment of rats with either phenobarbital or ethanol. Phenobarbital increased the activity of gamma-glutamyltransferase in microvessels, without alteration of synaptic membranes activity. An increase of enzyme activity was also obtained after a chronic intoxication with ethanol. These results suggest that the isoform of gamma-glutamyltransferase localized in brain microvessels may respond to exogenous inducers.

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