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Case Reports
. 2017 Oct;21(4):e48-e51.
doi: 10.1097/LGT.0000000000000330.

Zoon Vulvitis Treated Successfully With Platelet-Rich Plasma: First Case Reported

July Jaimes Suarez  1 , Luis Vidal Conde, Rafael Collazos Robles, Joaquin Grande Gomez, Victor Martin Díaz, Oscar Parra Rodriguez, Yosmar Carolina Pérez-González
Affiliations
Case Reports

Zoon Vulvitis Treated Successfully With Platelet-Rich Plasma: First Case Reported

July Jaimes Suarez et al. J Low Genit Tract Dis. 2017 Oct.

Abstract

Chronic Zoon vulvitis was successfully treated with platelet-rich plasma achieving a considerable reduction of the clinical symptoms and signs of an evident lesion.

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Conflict of interest statement

The authors have declared they have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Zoon vulvitis histopathological examination before treatment shows a epidermal thinning, presence of distinctive lozenge-shaped keratinocytes with sparse dyskeratosis and spongiosis, and a dense inflammatory infiltrate of (A) T-lymphocytes (CD3+), (B) B-Lymphocytes (CD20+), and (C) plasma cells (CD138+) being more remarkably in the upper dermis. Immunohistochemical staining, original magnification, ×400 (A, B) and ×200 (C).
FIGURE 2
FIGURE 2
Zoon vulvitis histopathological examination before treatment. A, Hematoxilin-eosin staining, original magnification ×400. B, Perl prussian blue staining technique for hemosiderin deposits, original magnification ×200.
FIGURE 3
FIGURE 3
A, Macroscopic appearance of Zoon vulvitis before PRP treatment: atrophic pale mucosa and a u-shaped bright erythema in vulvar introitus. B, Dermatological examination of the vulva after PRP treatment at 6 months, showing a reduction of the erythematous halo, a more vascularized vulva without dryness, and the presence of mucus. Triangles demarcate the margin of the lesion.
None
See this image and copyright information in PMC

References

    1. Salopek TG, Siminoski K. Vulvitis circumscripta plasmacellularis (Zoon's vulvitis) associated with autoimmune polyglandular endocrine failure. Br J Dermatol 1996;135:991–4. - PubMed
    1. Schafer AI. Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. J Clin Pharmacol 1995;35:209–19. - PubMed
    1. Botros SM, Dieterich M, Sand PK, et al. Successful treatment of Zoon's vulvitis with high potency topical steroid. Int Urogynecol J Pelvic Floor Dysfunct 2006;17:178–9. - PubMed
    1. Goldstein AT, Christopher K, Burrows LJ. Plasma cell vulvitis: a rare cause of intractable vulvar pruritus. Arch Dermatol 2005;141:789–90. - PubMed
    1. Gurumurthy M, Cairns M, Cruickshank M. Case series of Zoon vulvitis. J Low Genit Tract Dis 2010;14:56–8. - PubMed

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