Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987;73(2):110-4.
doi: 10.1007/BF00693775.

Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss

F F Johansen, J Zimmer, N H Diemer

Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss

F F Johansen et al. Acta Neuropathol. 1987.

Abstract

Somatostatin (SS)- and cholecystokinin (CCK)-immunopositive cell somata in the rat hippocampus were quantitated at day 1, 2, 3 and 4 after cerebral ischemia. A significant (P less than 0.01) 60%-80% loss of hilar and CA-3c SS neurons took place. No CCK neurons were lost. Damage to SS neurons was significant on the second postischemic day and preceded the delayed loss of CA-1 neurons. We speculate that loss of SS neurons, which presumably innervate the inhibitory GABAergic (gamma-aminobutyric acid) interneurons, may induce hyperactivity stimulating the Ca-1 neurons to death.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Stroke. 1979 May-Jun;10(3):267-72 - PubMed
    1. Brain Res. 1981 Dec 28;230(1-2):346-50 - PubMed
    1. J Comp Neurol. 1984 Aug 10;227(3):331-47 - PubMed
    1. Acta Neuropathol. 1975 Aug 27;32(3):209-23 - PubMed
    1. J Comp Neurol. 1984 Nov 1;229(3):374-92 - PubMed

LinkOut - more resources