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. 2017 Sep;43(3):378-382.
doi: 10.5152/tud.2017.32067. Epub 2017 Aug 3.

Renal angiomyoadenomatous tumour

P S Jayalakshmy  1 , Merin Jose  1 , M Feroze  1 , Rajesh K Kumar  2
Affiliations

Renal angiomyoadenomatous tumour

P S Jayalakshmy et al. Turk J Urol. 2017 Sep.

Abstract

Renal angiomyoadenomatous tumour is a newly described rare neoplasm. This tumour is characterised microscopically by admixture of three components- epithelial cells arranged in tubules and nests, angiomyomatous stroma and capillary sized interconnecting vascular channels in close association with the epithelial cell clusters. Microscopically it has wide range of differential diagnoses which include mixed epithelial and stromal tumour of kidney, angiomyolipoma and clear cell renal cell carcinoma with angiomyolipomatous/angiomyoadenomatous areas. Renal angiomyoadenomatous tumour should be differentiated from these tumours. Till now, only 10 cases have been reported in English medical literature. Here, we are reporting a case of renal angiomyoadenomatous tumour in a 29 year- old female patient who presented with hematuria and low backache and describing its main features so as to differentiate this entity from other renal tumours. To the best of our knowledge, this is the first case to be reported from India.

Keywords: Labrynthine vascular channels; rare renal tumour; renal angiomyoadenomatous tumour.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
Abdominal computed tomography showing tumor in the right kidney (arrow)
Figure 2
Figure 2
Cut section of kidney showing circumscribed tumour with grey- white and brownish areas
Figure 3. a–d
Figure 3. a–d
The three components of the tumour-epithelial, smooth muscle and vascular (H&E × 40) (a). Epithelial component arranged in glandular/tubular pattern with basally located bland nuclei and intimately surrounded by thin vascular channels (H&E × 400) (b). Epithelial tissue surrounded by smooth muscle bundles (H&E × 400). (c) Thick fibrovascular capsule separating tumour (left) from normal renal tissue (right) (H&E × 400) (d)
Figure 4. a–d
Figure 4. a–d
High power view of thin anastomosing vascular channels surrounded by pericyte-like cells (H&E × 400) (a). Metaplastic stromal cartilage/bone (H&E × 400) (b). Edematous/Hyalinized areas with inflammatory cells (H&E × 400) (c, d)
Figure 5
Figure 5
IHC PANEL. Pan CK & CK7 positive in epithelial cells. CD34- Positive in vascular channels. Vimentin & CD10- Focally positive. SMA: Positive in smooth muscle bundles. Ki67- Low proliferative index. ER & HMB 45- Negative
See this image and copyright information in PMC

Comment in

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