In memory of Norman Bowery (1944-2016)

Abstract

This article is in memory of Professor Norman Bowery (1944-2016). Norman was a pharmacologist who spent most of his career researching the pharmacology of γ-aminobutyric acid (GABA). He discovered a novel metabotropic receptor subtype, GABA_B, that is pharmacologically, and structurally different from the original ionotropic receptor now designated as GABA_A. In his research he also studied the neurotransmitters glutamate and substance P, two molecules whose release in parts of the spinal cord is inhibited by baclofen a GABA_B receptor agonist. Norman was interested in the therapeutic potential of interacting with the GABA_B receptor, in particular spasticity, pain and absence epilepsy.