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Comment
. 2017 Oct;7(10):1052.
doi: 10.1158/2159-8290.CD-NB2017-122. Epub 2017 Sep 1.

CDK4/6 Inhibitors Induce Antitumor Immunity

No authors listed
Comment

CDK4/6 Inhibitors Induce Antitumor Immunity

No authors listed. Cancer Discov. 2017 Oct.

Abstract

CDK4/6 inhibitors not only induce cell-cycle arrest but also promote antitumor immunity by stimulating the production of type III interferons, which enhance tumor antigen presentation, and suppress regulatory T cells. The immune effects of these drugs provide a rationale for combining CDK4/6 inhibitors with checkpoint blockade agents.

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  • CDK4/6 inhibition triggers anti-tumour immunity.
    Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, Khan N, Ubellacker JM, Xie S, Metzger-Filho O, Hoog J, Ellis MJ, Ma CX, Ramm S, Krop IE, Winer EP, Roberts TM, Kim HJ, McAllister SS, Zhao JJ. Goel S, et al. Nature. 2017 Aug 24;548(7668):471-475. doi: 10.1038/nature23465. Epub 2017 Aug 16. Nature. 2017. PMID: 28813415 Free PMC article.

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