Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Sep;7(9):934-936.
doi: 10.1158/2159-8290.CD-17-0704.

Fast-TRKing Drug Development for Rare Molecular Targets

Aparna R Parikh  1 , Ryan B Corcoran  2
Affiliations
Comment

Fast-TRKing Drug Development for Rare Molecular Targets

Aparna R Parikh et al. Cancer Discov. 2017 Sep.

Abstract

<b/> Drug development for rare molecular targets in oncology presents unique challenges. In this issue of Cancer Discovery, Drilon and colleagues report the accelerated development and innovative initial clinical trial strategy of a next-generation TRK inhibitor, LOXO-195, designed to overcome common secondary TRK resistance mutations. Cancer Discov; 7(9); 934-6. ©2017 AACR.See related article by Drilon et al., p. 963.

PubMed Disclaimer

Comment on

LinkOut - more resources