Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun:37:150-154.
doi: 10.1016/j.mib.2017.08.003. Epub 2017 Aug 31.

Type III CRISPR-Cas systems: when DNA cleavage just isn't enough

Nora C Pyenson  1 , Luciano A Marraffini  2
Affiliations
Review

Type III CRISPR-Cas systems: when DNA cleavage just isn't enough

Nora C Pyenson et al. Curr Opin Microbiol. 2017 Jun.

Abstract

Type III CRISPR-Cas systems have a unique targeting mechanism that requires the transcription of the DNA target and results in the degradation of not only the genome of the invader but also its transcripts. Here we discuss the most recent studies describing dual DNA and RNA targeting by these systems, as well as the implications of this complex molecular mechanism for immunity in vivo.

PubMed Disclaimer

LinkOut - more resources