Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer

Abstract

Objective: To investigate whether serum antimüllerian hormone (AMH) levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer (IVF-ET).

Design: Cohort study.

Setting: University-affiliated IVF-ET center.

Patient(s): A total of 1,060 patients who attained a clinical pregnancy after IVF-ET.

Interventions(s): Centralized serum AMH measurements were performed within the 12 months before IVF-ET. Binary logistic regression was used to verify whether serum AMH levels were associated with the occurrence of a miscarriage independently from confounding factors, such as age and intensity of ovarian response to controlled ovarian stimulation assessed by the number of oocytes retrieved.

Main outcome measure(s): Miscarriage rates.

Result(s): In patients displaying reduced serum AMH levels, miscarriage rates were significantly increased independently from age and the number of oocytes retrieved.

Conclusion(s): The present data indicate that serum AMH levels are independently associated with the occurrence of a miscarriage after IVF-ET.

Keywords: Antimüllerian hormone; biomarkers; in vitro fertilization; miscarriage; oocyte quality.