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. 2017 Sep;33(9):449-452.
doi: 10.1016/j.kjms.2017.06.012. Epub 2017 Jul 13.

Placental apoptosis in recurrent miscarriage

Tarek A Atia  1
Affiliations

Placental apoptosis in recurrent miscarriage

Tarek A Atia. Kaohsiung J Med Sci. 2017 Sep.

Abstract

Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage (RM). Placental tissue samples were collected from 40 women with RM (study group) and 30 women with sporadic spontaneous abortion (control group). Samples were prepared and stained immunohistochemically with markers for both the apoptotic protein (p53) and anti-apoptotic Bcl-2 antibodies. Our results showed that expression of the apoptotic (p53) protein was significantly increased in the placental tissues of the RM group (p = 0.003). By contrast, the expression of anti-apoptotic (Bcl-2) antibodies was significantly increased in the placental tissues of the control group (p = 0.025). We concluded that placental apoptosis plays a crucial role in pregnancy continuation. However, increased p53 expression in placental tissue in early pregnancy could negatively affect pregnancy continuation.

Keywords: Apoptosis; Immunohistochemistry; Placenta; RM.

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Figures

Figure 1
Figure 1
Immunohistochemistry staining the expression of apoptotic protein (p53) in the trophoblast cells of the chorionic villi of RM cases (A), which is significantly higher than that of sporadic abortion cases (B) [P = 0.003] [×400].
Figure 2
Figure 2
Immunohistochemistry staining the expression of anti‐apoptotic protein (Bcl‐2) in the trophoblast cells of the chorionic villi of RM cases (A), which is significantly decreased than that of the sporadic abortion cases (B) [P = 0.025] [×400].
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