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Comment
. 2017 Oct;153(4):1162-1163.
doi: 10.1053/j.gastro.2017.08.050. Epub 2017 Sep 1.

Progress in PD-1-based Immunotherapy: New Mechanistic Insight May Provide Expanded Hope for Application to Colon and Gastrointestinal Cancers

Haeseong Park  1 , Baosheng Chen  1 , Matthew A Ciorba  1
Affiliations
Comment

Progress in PD-1-based Immunotherapy: New Mechanistic Insight May Provide Expanded Hope for Application to Colon and Gastrointestinal Cancers

Haeseong Park et al. Gastroenterology. 2017 Oct.
No abstract available

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  • Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.
    Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai RN, Ramalingam SS, Araki K, Ahmed R. Kamphorst AO, et al. Science. 2017 Mar 31;355(6332):1423-1427. doi: 10.1126/science.aaf0683. Epub 2017 Mar 9. Science. 2017. PMID: 28280249 Free PMC article.

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