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. 2017;65(9):840-847.
doi: 10.1248/cpb.c17-00314.

Four New Lignans and IL-2 Inhibitors from Magnoliae Flos

Thi Tuyet Mai Nguyen  1 , Hyun-Su Lee  2   3 , Thi Thu Nguyen  1 , Thi Quynh Mai Ngo  2 , Chang-Duk Jun  3 , Byung Sun Min  2 , Jeong Ah Kim  1
Affiliations
Free article

Four New Lignans and IL-2 Inhibitors from Magnoliae Flos

Thi Tuyet Mai Nguyen et al. Chem Pharm Bull (Tokyo). 2017.
Free article

Abstract

Four new lignans, a furofuran lignan medioresinol B (10) and three tetrahydrofuran lignans kobusinol C (16), 7'-methoxy magnostellin A (21), and mangnostellin D (23), along with 19 known lignans, were isolated from the flower buds of Magnolia biondii PAMP. The structures of the isolates were elucidated using spectroscopic analysis, mainly one- and two-dimensional NMR, high resolution-MS, and circular dichroism techniques as well as Mosher's esterification method. The anti-allergic effects of the isolated compounds were evaluated by analyzing the inhibition of interleukin-2 (IL-2) expression in Jurkat T-cells. Compounds 11-14 reduced IL-2 expression in a dose-dependent manner.

Keywords: Magnolia biondii PAMP.; Magnoliaceae; anti-allergy; interleukin-2; lignan.

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