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. 2017;65(9):869-873.
doi: 10.1248/cpb.c17-00163.

New Iridoids from Scrophularia ningpoensis

Qing-Juan Ma  1 , Li Han  1 , Yu Mu  1 , Pei-Pei Guan  1 , Hui Lei  1 , Zhan-You Wang  1 , Xue-Shi Huang  1
Affiliations
Free article

New Iridoids from Scrophularia ningpoensis

Qing-Juan Ma et al. Chem Pharm Bull (Tokyo). 2017.
Free article

Abstract

Five new compounds including five iridoids (1-5) and six known compounds were isolated from the rhizomes of Scrophularia ningpoensis. Their structures were determined by extensive NMR and IR, MS spectroscopic data analyses. The anti-inflammatory, antibacterial, antifungal, and cytotoxic activities of the isolated compounds were evaluated. Compound 11 exhibited significant inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells.

Keywords: Scrophularia ningpoensis; anti-inflammatory; iridoid; pyrrolidin-2-one.

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