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Review
. 2017 Jun;20(6):604-612.
doi: 10.22038/IJBMS.2017.8827.

Bio-effectiveness of the main flavonoids of Achillea millefolium in the pathophysiology of neurodegenerative disorders- a review

Fatemeh Ayoobi  1 , Ali Shamsizadeh  1   2 , Iman Fatemi  1   2 , Alireza Vakilian  3   4 , Mohammad Allahtavakoli  1   2 , Gholamhossein Hassanshahi  5 , Amir Moghadam-Ahmadi  4   6
Affiliations
Review

Bio-effectiveness of the main flavonoids of Achillea millefolium in the pathophysiology of neurodegenerative disorders- a review

Fatemeh Ayoobi et al. Iran J Basic Med Sci. 2017 Jun.

Abstract

The Achillea millefolium L. (Yarrow) is a common herb which is widely being used, worldwide. Achillea is being used for treatment of many disorders since centuries. It is considered safe for supplemental use and flavonoids such as kaempferol, luteolin and apigenin are of main constituents present in Achillea. Most of both antioxidant and anti-inflammatory properties of this herb have been attributed to its flavonoid content. Oxidative and inflammatory processes play important roles in pathogenesis of neurodegenerative diseases. Present review was aimed to review the latest literature evidences regarding application of Achillea and/or its three main flavonoid constituents on epilepsy, Alzheimer's disease, multiple sclerosis, Parkinson's disease and stroke.

Keywords: Achillea millefolium; Flavonoids; Medicinal; Neurodegenerative – disease; Plants.

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Figures

Figure 1
Figure 1
Achillea millefolium L.
Figure 2
Figure 2
Chemical structure of main flavonoids of Achillea millefolium L.
Figure 3
Figure 3
Schematic description for protective mechanisms of Achillea millefolium L. in ameliorating neurodegenerative diseases
See this image and copyright information in PMC

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