WHO Needs High FIO₂?

Ozan Akca¹, Lorenzo Ball², F Javier Belda³, Peter Biro⁴, Andrea Cortegiani⁵, Arieh Eden⁶, Carlos Ferrando³, Luciano Gattinoni⁷, Zeev Goldik⁶, Cesare Gregoretti⁵, Thomas Hachenberg⁸, Göran Hedenstierna⁹, Harriet W Hopf¹⁰, Thomas K Hunt¹¹, Paolo Pelosi², Motaz Qadan¹², Daniel I Sessler¹³, Marina Soro³, Mert Şentürk¹⁴

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, Neuroscience ICU, University of Louisville, Kentucky, USA.
² IRCCS AOU San Martino-IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
³ Department of Anesthesiology and Critical Care, Hospital Clinico Universitario, University of Valencia, Valencia, Spain.
⁴ Institute of Anesthesiology, University Hospital Zurich, Switzerland.
⁵ Department of Biopathology and Medical Biotechnologies (DIBIMED), Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone. University of Palermo, Italy.
⁶ Department of Anesthesiology, Critical Care and Pain Medicine, Lady Davis Carmel Medical Center, Haifa, Israel.
⁷ Department of Anesthesiology Emergency & Intensive Care Medicine, Gottingen University, Gottingen, Germany.
⁸ Department of Anaesthesiology and Intensive Care Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
⁹ Clinical Physiology, Uppsala University, Sweden.
¹⁰ Department of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
¹¹ Division of General Surgery, University of California, San Francisco, USA.
¹² Massachusetts General Hospital, Department of Surgery, Harvard University, Massachusetts, USA.
¹³ Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA.
¹⁴ Department of Anaesthesiology and Reanimation, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.

PMID: 28868164
PMCID: PMC5579210
DOI: 10.5152/TJAR.2017.250701

WHO Needs High FIO₂?

Ozan Akca et al. Turk J Anaesthesiol Reanim. 2017 Aug.

. 2017 Aug;45(4):181-192.

doi: 10.5152/TJAR.2017.250701. Epub 2017 Aug 1.

Authors

Affiliations

¹ Department of Anesthesiology and Perioperative Medicine, Neuroscience ICU, University of Louisville, Kentucky, USA.
² IRCCS AOU San Martino-IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.
³ Department of Anesthesiology and Critical Care, Hospital Clinico Universitario, University of Valencia, Valencia, Spain.
⁴ Institute of Anesthesiology, University Hospital Zurich, Switzerland.
⁵ Department of Biopathology and Medical Biotechnologies (DIBIMED), Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone. University of Palermo, Italy.
⁶ Department of Anesthesiology, Critical Care and Pain Medicine, Lady Davis Carmel Medical Center, Haifa, Israel.
⁷ Department of Anesthesiology Emergency & Intensive Care Medicine, Gottingen University, Gottingen, Germany.
⁸ Department of Anaesthesiology and Intensive Care Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
⁹ Clinical Physiology, Uppsala University, Sweden.
¹⁰ Department of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
¹¹ Division of General Surgery, University of California, San Francisco, USA.
¹² Massachusetts General Hospital, Department of Surgery, Harvard University, Massachusetts, USA.
¹³ Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA.
¹⁴ Department of Anaesthesiology and Reanimation, İstanbul University İstanbul School of Medicine, İstanbul, Turkey.

PMID: 28868164
PMCID: PMC5579210
DOI: 10.5152/TJAR.2017.250701

Abstract

World Health Organization and the United States Center for Disease Control have recently recommended the use of 0.8 FIO₂ in all adult surgical patients undergoing general anaesthesia, to prevent surgical site infections. This recommendation has arisen several discussions: As a matter of fact, there are numerous studies with different results about the effect of FIO₂ on surgical site infection. Moreover, the clinical effects of FIO₂ are not limited to infection control. We asked some prominent authors about their comments regarding the recent recommendations.

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References

1. Greif R, Akça O, Horn E-P, Kurz A, Sessler DI Outcomes Research™ Group. Supplemental perioperative oxygen to reduce the incidence of surgical wound infection. N Engl J Med. 2000;342:161–7. https://doi.org/10.1056/NEJM200001203420303. - DOI - PubMed
1. Gottrup F, Firmin R, Rabkin J, Halliday BJ, Hunt TK. Directly measured tissue oxygen tension and arterial oxygen tension assess tissue perfusion. Crit Care Med. 1987;15:1030–6. https://doi.org/10.1097/00003246-198711000-00008. - DOI - PubMed
1. Sheffield CW, Sessler DI, Hopf HW, Schroeder M, Moayeri A, Hunt TK, et al. Centrally and locally mediated thermoregulatory responses alter subcutaneous oxygen tension. Wound Repair Regen. 1996;4:339–45. https://doi.org/10.1046/j.1524-475X.1996.40310.x. - DOI - PubMed
1. Akça O, Melischek M, Scheck T, Hellwagner K, Arkiliç C, Kurz A, et al. Postoperative pain and subcutaneous oxygen tension. Lancet. 1999;354:41–2. https://doi.org/10.1016/S0140-6736(99)00874-0. - DOI - PubMed
1. Arkilic CF, Taguchi A, Sharma N, Ratnaraj J, Sessler DI, Read TE, et al. Supplemental perioperative fluid administration increases tissue oxygen pressure. Surgery. 2003;133:49–55. https://doi.org/10.1067/msy.2003.80. - DOI - PubMed

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WHO Needs High FIO₂?

Affiliations

WHO Needs High FIO₂?

Authors

Affiliations

Abstract

References

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