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. 2017 Dec;32(6):2143-2147.
doi: 10.1007/s11011-017-0105-2. Epub 2017 Sep 3.

In human brain ornithine transcarbamylase (OTC) immunoreactivity is strongly expressed in a small number of nitrergic neurons

Hans-Gert Bernstein  1 , Hendrik Dobrowolny  2 , Gerburg Keilhoff  3 , Johann Steiner  2
Affiliations

In human brain ornithine transcarbamylase (OTC) immunoreactivity is strongly expressed in a small number of nitrergic neurons

Hans-Gert Bernstein et al. Metab Brain Dis. 2017 Dec.

Abstract

There is recent evidence for ornithine transcarbamylase (OTC) expression in adult human brain. We decided to immunocytochemically map OTC throughout brain, and to further characterize OTC-immunopositive neurons. By using double immunolabeling technique for OTC and neuronal nitric oxide synthase (nNOS) OTC protein expression was revealed in a small subset of nitrergic (nNOS) neurons. Since citrulline (the reaction product of OTC) enhances the bioavailability of L-arginine, the substrate of nNOS, it is conceivable that OTC activity supports NO production in nitrergic neurons.

Keywords: Human brain; Immunocytochemistry; Neuronal nitric oxide synthase; Ornithine transcarbamylase.

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