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. 2017 Oct 11;139(40):13989-13992.
doi: 10.1021/jacs.7b07388. Epub 2017 Sep 7.

Enantioselective Total Synthesis of (-)-Pavidolide B

Peng-Peng Zhang  1 , Zhi-Ming Yan  1 , Yuan-He Li  2 , Jian-Xian Gong  1 , Zhen Yang  1   2   3
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Enantioselective Total Synthesis of (-)-Pavidolide B

Peng-Peng Zhang et al. J Am Chem Soc. .

Abstract

The enantioselective synthesis of (-)-pavidolide B (1) was achieved in a linear sequence of 10 steps. The key steps are (a) an enantioselective organocatalytic cyclopropanation; (b) a radical-based cascade annulation for the regio- and diastereo-selective synthesis of the highly functionalized lactone 3 bearing the characteristic tricyclic core and seven contiguous stereocenters;

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