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. 1987 Jul;104(7):69-71.

[Effect of cholinergic stimulation on spontaneous lymphocyte adhesion in vitro]

[Article in Russian]
D D Kharkevich
  • PMID: 2887218

[Effect of cholinergic stimulation on spontaneous lymphocyte adhesion in vitro]

[Article in Russian]
D D Kharkevich. Biull Eksp Biol Med. 1987 Jul.

Abstract

With the help of spontaneous lymphocyte adhesion test it was demonstrated that acetylcholine and carbacholine enhanced the adhesion of lymphocytes. The enhancement revealed was completely abolished by a specific M-cholinergic blocker--atropine, but not N-cholinergic blocker--hexonium. Thus, the enhancement of spontaneous human lymphocyte adhesion by cholinergic stimulation is mediated by M-cholinoreceptors. It is suggested that the phenomenon revealed is mediated by the enhancement of cGMP intracellular levels after cholinergic stimulation.

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