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. 2017 Jul 1;55(5):573-578.
doi: 10.1093/mmy/myw105.

Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1

Maike Hefter  1 , Jasmin Lother  1 , Esther Weiß  1 , Anna Lena Schmitt  1 , Mirjam Fliesser  1 , Hermann Einsele  1 , Juergen Loeffler  1
Affiliations

Human primary myeloid dendritic cells interact with the opportunistic fungal pathogen Aspergillus fumigatus via the C-type lectin receptor Dectin-1

Maike Hefter et al. Med Mycol. .

Abstract

Aspergillus fumigatus is an opportunistic fungal pathogen causing detrimental infections in immunocompromised individuals. Dendritic cells (DCs) are potent antigen-presenting cells and recognize the A. fumigatus cell wall component β-1,3 glucan via Dectin-1, followed by DC maturation and cytokine release. Here, we demonstrate that human primary myeloid DCs (mDCs) interact with different morphotypes of A. fumigatus. Dectin-1 is expressed on mDCs and is down-regulated after contact with A. fumigatus, indicating that mDCs recognize A. fumigatus via this receptor. Blocking of Dectin-1, followed by stimulation with depleted zymosan diminished the up-regulation of the T-cell co-stimulatory molecules CD40, CD80, HLA-DR and CCR7 on mDCs and led to decreased release of the cytokines TNF-α, IL-8, IL-1β and IL-10.

Keywords: Aspergillus fumigatus; Dectin-1; blocking antibody; dendritic cells; myeloid.

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