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Case Reports
. 2017 Sep 6;11(1):215.
doi: 10.1186/s13256-017-1379-z.

Ureter metastatic castration-resistant prostate cancer: a case report

Sohgo Tsutsumi  1 , Takashi Kawahara  2 , Yusuke Hattori  1 , Taku Mochizuki  1 , Jun-Ichi Teranishi  1 , Yasuhide Miyoshi  1 , Sawako Chiba  3 , Hiroji Uemura  1
Affiliations
Case Reports

Ureter metastatic castration-resistant prostate cancer: a case report

Sohgo Tsutsumi et al. J Med Case Rep. .

Abstract

Background: In most cases, prostate cancer metastasizes to the lymph nodes, bone, and liver. In very rare cases, it metastasizes to the ureter. Due to the difficulty in making a preoperative diagnosis, ureteral metastasis from prostate cancer is typically diagnosed after nephroureterectomy.

Case presentation: A 77-year-old Asian Japanese man with right hydronephrosis and hydroureter was referred to our hospital to undergo further examination due to the suspicion of ureteral cancer. He had been diagnosed 2 years previously with prostate cancer with a Gleason score of 4+5=9. He received radiotherapy and androgen deprivation therapy. A nephroureterectomy was performed for suspected right ureteral cancer. On the basis of a histopathological examination, poorly differentiated adenocarcinoma was suspected, and the tumor cells were positive for prostate-specific antigen immunohistochemically.

Conclusions: We herein report a rare case of ureteral metastasis in castration resistant prostate cancer.

Keywords: Female PSA; Skene’s gland adenocarcinoma; Skene’s gland cancer.

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Conflict of interest statement

Ethics approval and consent to participate

The present study was approved by the institutional review board of Yokohama City University Medical Center.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Competing interests

The authors declare that they have no competing interests.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Computed tomographic findings of (a) hydronephrosis and (b) the patient’s tumor (arrow)
Fig. 2
Fig. 2
Retrograde pyelonephrography. Stenosis was observed in the lower ureter (arrow)
Fig. 3
Fig. 3
Pathological images. a Ureteral epithelium was intact. Solid metastatic nest in intra- and extraureteral wall (hematoxylin and eosin stain, original magnification ×12.5). b Tumor showed a little glandular differentiation (hematoxylin and eosin stain, original magnification ×400). c Tumor cells stained positive for prostate-specific antigen (original magnification ×200)
See this image and copyright information in PMC

References

    1. Disibio G, French SW. Metastatic patterns of cancers: results from a large autopsy study. Arch Pathol Lab Med. 2008;132(6):931–9. - PubMed
    1. Otta RJ, Gordillo C, Fernández I. Ureteral metastasis of a prostatic adenocarcinoma. Can Urol Assoc J. 2015;9(3-4):E153–5. doi: 10.5489/cuaj.2500. - DOI - PMC - PubMed
    1. Carson WJ. Metastatic carcinoma in the ureter: report of additional cases. Ann Surg. 1927;86(4):549–55. doi: 10.1097/00000658-192710000-00010. - DOI - PMC - PubMed
    1. Fitch WP, Robinson JR, Radwin HW. Metastatic carcinoma of the ureter. Arch Surg. 1976;111(8):874–6. doi: 10.1001/archsurg.1976.01360260042010. - DOI - PubMed
    1. Zhang D, Li H, Gan W. Hydronephrosis associated with ureteral metastasis of prostate cancer: a rare case report. Mol Clin Oncol. 2016;4(4):597–8. - PMC - PubMed

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