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. 2017 Sep 26;15(37):7796-7801.
doi: 10.1039/c7ob01924f.

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Jiaan Shao  1 , Richard A Houghten, Colette T Dooley, Margret Cazares, Jay P McLaughlin, Shainnel O Eans, Michelle L Ganno, Michelle R Hoot, Marc A Giulianotti, Yongping Yu
Affiliations

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Jiaan Shao et al. Org Biomol Chem. .

Abstract

A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.

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