Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Sep;80(3):804-11.
doi: 10.1172/JCI113137.

Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system

C J Thiele, C McKeon, T J Triche, R A Ross, C P Reynolds, M A Israel

Differential protooncogene expression characterizes histopathologically indistinguishable tumors of the peripheral nervous system

C J Thiele et al. J Clin Invest. 1987 Sep.

Abstract

We have found highly predictable patterns of protooncogene expression in cell lines and tumor tissue of neuroblastoma (NB), a tumor of the peripheral nervous system (PNS). These patterns make it possible to recognize two different genetically definable subgroups among histopathologically indistinguishable tumors. Additionally, we have identified a difference in neurotransmitter biosynthetic enzyme activity in these two subgroups of NB. The patterns of protooncogene expression and neurotransmitter biosynthetic enzymes suggests that these tumors arise in different cells of the PNS.

PubMed Disclaimer

References

    1. Cancer Res. 1970 Aug;30(8):2110-8 - PubMed
    1. Cancer Res. 1973 Nov;33(11):2643-52 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Cancer. 1976 Mar;37(3):1334-51 - PubMed
    1. Cancer Res. 1976 Sep;36(9 pt.1):3094-100 - PubMed

MeSH terms

Substances