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. 2018 Jan;45(1):39-41.
doi: 10.1097/OLQ.0000000000000687.

Reported Cases of Neurosyphilis Among Early Syphilis Cases-United States, 2009 to 2015

Affiliations

Reported Cases of Neurosyphilis Among Early Syphilis Cases-United States, 2009 to 2015

Alex de Voux et al. Sex Transm Dis. 2018 Jan.

Abstract

The surveillance of neurosyphilis, an uncommon but severe consequence of syphilis, is complex; surveillance classification of neurosyphilis requires a lumbar puncture and cerebrospinal fluid analysis. We examined the prevalence of reported neurosyphilis among primary, secondary, and early latent syphilis cases reported in the United States from 2009 to 2015. Overall, the prevalence of reported neurosyphilis from 2009 to 2015 was low (0.84%); however, this is likely an underestimate of the true burden in the United States.

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Conflict of interest statement

Conflict of Interest and Sources of Funding: None declared.

Figures

Figure 1
Figure 1
Early syphilis—reported cases and prevalence of neurosyphilis by year, from 10 states, 2009 to 2015.

References

    1. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2015. Atlanta: U.S. Department of Health and Human Services; 2016. Available at: https://www.cdc.gov/std/stats.
    1. Dombrowski JC, Pedersen R, Marra CM, et al. Prevalence estimates of complicated syphilis. Sex Transm Dis. 2015;42:702–704. - PubMed
    1. Taylor MM, Aynalem G, Olea LM, et al. A consequence of the syphilis epidemic among men who have sex with men (MSM): Neurosyphilis in Los Angeles, 2001–2004. Sex Transm Dis. 2008;35:430–434. - PMC - PubMed
    1. Centers for Disease Control and Prevention. Symptomatic early neurosyphilis among HIV-positive men who have sex with men—Four cities, United States, January 2002–June 2004. MMWR Morb Mortal Wkly Rep. 2007;56:625–628. - PMC - PubMed
    1. Centers for Disease Control and Prevention. [Accessed February 23, 2017];Clinical advisory: Ocular syphilis in the United States 2015. Available at: http://www.cdc.gov/std/syphilis/clinicaladvisoryos2015.htm.

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