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. 2018 Feb;65(2):10.1002/pbc.26788.
doi: 10.1002/pbc.26788. Epub 2017 Sep 6.

Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia

Diana J Moke  1 , Matthew J Oberley  2   3 , Deepa Bhojwani  1   3 , Chintan Parekh  1   3 , Etan Orgel  1   3
Affiliations

Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia

Diana J Moke et al. Pediatr Blood Cancer. 2018 Feb.

Abstract

While early studies reported superior survival for cancer patients enrolled on clinical trials, recent findings are inconclusive. We investigated the association between enrollment on contemporary trials and event-free survival (EFS) in pediatric B-cell acute lymphoblastic leukemia (B-ALL). In a retrospective cohort of 274 children (1-21 years) treated for B-ALL from 2008 to 2015, 55.5% enrolled with no disparity in enrollment by age, sex, or ethnicity. Three-year EFS was similar for enrolled and not enrolled patients (90.1% [95% CI, 82.5-94.5] versus 86.5% [95% CI, 77.7-92.0]). Clinical trial enrollment did not affect pediatric B-ALL survival, albeit in a limited-size cohort treated at a single academic institution.

Keywords: clinical trial enrollment; clinical trial participation; disparities; pediatric B-cell acute lymphoblastic leukemia; survival.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare that there is no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Kaplan–Meier survival curves of event-free survival (A) and overall survival (B) for not enrolled (blue solid line) and enrolled (red dashed line) patients. LRT, log-rank test P-value
See this image and copyright information in PMC

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