Review

Glycomics and Glycoproteomics

Pauline Rudd, Niclas G. Karlsson, Kay-Hooi Khoo, Nicolle H. Packer

, editors.

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 51.

2017.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876822
Bookshelf ID: NBK453015
DOI: 10.1101/glycobiology.3e.051

Free Books & Documents

Review

Glycomics and Glycoproteomics

Pauline Rudd et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 51.

2017.

Authors

Pauline Rudd, Niclas G. Karlsson, Kay-Hooi Khoo, Nicolle H. Packer

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876822
Bookshelf ID: NBK453015
DOI: 10.1101/glycobiology.3e.051

Excerpt

The term “glycomics” currently describes studies designed to define the complete repertoire of glycans that a cell or tissue produces under specified conditions of time, location, and environment. “Glycoproteomics” describes this glycome as it appears on the cellular proteome. Glycoproteomics determines which sites on each glycoprotein of a cell are glycosylated and ideally includes the identification and quantitation of each glycan structure at each site on the heterogeneous glycoforms in the cell. This complexity makes glycomics and glycoproteomics both exciting and daunting. Because neither the proteome nor the transcriptome can accurately predict such a moving target, the glycome and glycoproteome must be analyzed directly, and the techniques used to characterize the glycome and glycoproteome are described in this chapter. Analyses of glycolipids and free glycans are described in other chapters.

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References

1. Berger EG, Buddecke E, Kamerling JP, Kobata A, Paulson JC, Vliegenthart JF. 1982. Structure, biosynthesis and functions of glycoprotein glycans. Experientia 38: 1129–1162. - PubMed
1. Domann PJ, Pardos-Pardos AC, Fernandes DL, Spencer DI, Radcliffe CM, Royle L, Dwek RA, Rudd PM. 2007. Separation-based glycoprofiling approaches using fluorescent labels. Proteomics 1: 70–76. - PubMed
1. Tissot B, North SJ, Ceroni A, Pang PC, Panico M, Rosati F, Capone A, Haslam SM, Dell A, Morris H. 2009. Glycoproteomics: Past, present and future. FEBS Lett 583: 1728–1735. - PMC - PubMed
1. Zaia J. 2010. Mass spectrometry and glycomics. OMICS 14: 401–418. - PMC - PubMed
1. Jensen PH, Karlsson NG, Kolarich D, Packer NH. 2012. Structural analysis of N- and O-glycans released from glycoproteins. Nat Protocols 7: 1299–1310. - PubMed

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Glycomics and Glycoproteomics

Book Affiliations

Glycomics and Glycoproteomics

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