Review

I-Type Lectins

Ajit Varki, Ronald L. Schnaar, Paul R. Crocker

, editors.

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 35.

2017.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876825
Bookshelf ID: NBK453073
DOI: 10.1101/glycobiology.3e.035

Free Books & Documents

Review

I-Type Lectins

Ajit Varki et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 35.

2017.

Authors

Ajit Varki, Ronald L. Schnaar, Paul R. Crocker

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876825
Bookshelf ID: NBK453073
DOI: 10.1101/glycobiology.3e.035

Excerpt

I-type lectins are glycan-binding proteins (excluding antibodies and T-cell receptors) in which the binding domain is homologous to the large and varied immunoglobulin superfamily (IgSF) of proteins. Among I-type lectins, the Siglec family of sialic acid–recognizing lectins is the best characterized subgroup, both structurally and functionally, and is therefore the major focus of this chapter. Details of these lectins' discovery, characterization, binding properties, and biology are provided, along with discussions of their functional roles in vertebrate biology, with most currently available information being in mammals.

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References

1. Powell LD, Varki A. 1995. I-type lectins. J Biol Chem 270: 14243–14246. - PubMed
1. van de Stolpe A, van der Saag PT. 1996. Intercellular adhesion molecule-1. J Mol Med (Berl) 74: 13–33. - PubMed
1. Crocker PR, Clark EA, Filbin M, Gordon S, Jones Y, Kehrl JH, Kelm S, Le Douarin N, Powell L, Roder J, et al. 1998. Siglecs: A family of sialic-acid binding lectins. Glycobiology 8: v–vi. - PubMed
1. Crocker PR, Varki A. 2001. Siglecs, sialic acids and innate immunity. Trends Immunol 22: 337–342. - PubMed
1. Angata T, Brinkman-Van der Linden E.. 2002. I-type lectins. Biochim Biophys Acta 1572: 294–316. - PubMed

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I-Type Lectins

Book Affiliations

I-Type Lectins

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Book Affiliations

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