Review

Proteoglycans and Sulfated Glycosaminoglycans

Ulf Lindahl, John Couchman, Koji Kimata, Jeffrey D. Esko

, editors.

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 17.

2017.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876828
Bookshelf ID: NBK453033
DOI: 10.1101/glycobiology.3e.017

Free Books & Documents

Review

Proteoglycans and Sulfated Glycosaminoglycans

Ulf Lindahl et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 17.

2017.

Authors

Ulf Lindahl, John Couchman, Koji Kimata, Jeffrey D. Esko

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876828
Bookshelf ID: NBK453033
DOI: 10.1101/glycobiology.3e.017

Excerpt

This chapter focuses on the structure, biosynthesis, and general biology of proteoglycans. Topics include a description of the major families of proteoglycans, their characteristic polysaccharide chains (glycosaminoglycans), biosynthetic pathways, and general concepts about proteoglycan function. Proteoglycans, like other glycoconjugates, have many essential roles in biology.

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References

1. Yurchenco PD. 2011. Basement membranes: Cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol 3: a004911. - PMC - PubMed
1. Lindahl U, Kjellén L. 2013. Pathophysiology of heparan sulphate: Many diseases, few drugs. J Intern Med 273: 555–571. - PubMed
1. Thacker BE, Xu D, Lawrence R, Esko JD. 2013. Heparan sulfate 3-O-sulfation: A rare modification in search of a function. Matrix Biol 35: 60–72. - PMC - PubMed
1. Vlodavsky I, Iozzo RV, Sanderson RD. 2013. Heparanase: Multiple functions in inflammation, diabetes and atherosclerosis. Matrix Biol 32: 220–222. - PubMed
1. Filmus J, Capurro M. 2014. The role of glypicans in Hedgehog signaling. Matrix Biol 35: 248–252. - PubMed

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Proteoglycans and Sulfated Glycosaminoglycans

Book Affiliations

Proteoglycans and Sulfated Glycosaminoglycans

Authors

Book Editors

Book Affiliations

Excerpt

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References

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