Review

O-GalNAc Glycans

, editors.

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 10.

2017.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876832
Bookshelf ID: NBK453030
DOI: 10.1101/glycobiology.3e.010

Free Books & Documents

Review

O-GalNAc Glycans

Inka Brockhausen et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 10.

2017.

Authors

Inka Brockhausen, Pamela Stanley

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876832
Bookshelf ID: NBK453030
DOI: 10.1101/glycobiology.3e.010

Excerpt

Many glycoproteins carry glycans initiated by GalNAc attached to the hydroxyl of Ser or Thr residues. Mucins are the class of glycoproteins carrying the greatest number of O-GalNAc glycans (also called mucin-type O-glycans), but this posttranslational modification is common among many glycoproteins. The sugars found in O-GalNAc glycans include GalNAc, Gal, GlcNAc, Fuc, and Sia, whereas Man, Glc, or Xyl residues are not represented. Sialic acids may be modified by O-acetylation, and Gal and GlcNAc by sulfation. The length of O-GalNAc glycans may vary from a single GalNAc to more than 20 sugar residues and can include blood group and other glycan epitopes. This chapter describes the structures, biosynthesis, and functions of O-GalNAc glycans in mammals.

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References

1. Fukuda M. 2002. Roles of mucin-type O-glycans in cell adhesion. Biochim Biophys Acta 1573: 394–405. - PubMed
1. Hollingsworth MA, Swanson BJ. 2004. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer 4: 45–60. - PubMed
1. Tarp MA, Clausen H. 2008. Mucin-type O-glycosylation and its potential use in drug and vaccine development. Biochim Biophys Acta 1780: 546–563. - PubMed
1. Brockhausen I. 2010. Biosynthesis of complex mucin-type O-glycans. In Comprehensive natural products. II: Chemistry and biology (ed. Mander L, Lui H-W, Wang PG.), Vol. 6, pp 315–350. Elsevier, Oxford.
1. Jensen PH, Kolarich D, Packer NH. 2010. Mucin-type O-glycosylation—Putting the pieces together. FEBS J 277: 81–94. - PubMed

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O-GalNAc Glycans

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O-GalNAc Glycans

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