Review

Nucleocytoplasmic Glycosylation

, editors.

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 18.

2017.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876834
Bookshelf ID: NBK453084
DOI: 10.1101/glycobiology.3e.018

Free Books & Documents

Review

Nucleocytoplasmic Glycosylation

Christopher M. West et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 18.

2017.

Authors

Christopher M. West, Gerald W. Hart

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876834
Bookshelf ID: NBK453084
DOI: 10.1101/glycobiology.3e.018

Excerpt

Although glycoconjugates predominate at the cell surface, in cellular secretions, and in the extracellular matrix, within the secretory pathway and lysosomes, there are also stable residential glycoproteins in the cytoplasm, nucleus, and plastids of eukaryotes. The prevalence of β-linked O-GlcNAc is so great in eukaryotes that an entire chapter is devoted to it (Chapter 19). This review discusses all other forms of cytoplasmic glycosylation, both established and speculative. The analysis begins with other well-documented forms of monoglycosylation in prokaryotes, expands to complex forms in protists, and provides examples of monoglycosylation exploited by bacterial toxins to co-opt processes vital to eukaryotes. In addition, conventional N-glycans are reported on a subset of mitochondrial and chloroplast proteins. Finally, the potential for a more extensive than currently appreciated occurrence of cytoplasmic glycosylation, as suggested by many examples of nuclear and cytoplasmic glycoproteins and glycosaminoglycans, which are yet to be confirmed by modern methods, is discussed. The numerous types of cytoplasmic and nuclear lectins that have been described are also reviewed.

PubMed Disclaimer

Sections

References

1. Marchase RB, Hiller AM. 1986. Glucose phosphotransferase and intracellular trafficking. Mol Cell Biochem 72: 101–107. - PubMed
1. Hart GW, Haltiwanger RS, Holt GD, Kelly WG. 1989. Glycosylation in the nucleus and cytoplasm. Annu Rev Biochem 58: 841–874. - PubMed
1. Chandra NC, Spiro MJ, Spiro RG. 1998. Identification of a glycoprotein from rat liver mitochondrial inner membrane and demonstration of its origin in the endoplasmic reticulum. J Biol Chem 273: 19715–19721. - PubMed
1. Lee JY, Spicer AP. 2000. Hyaluronan: A multifunctional, megadalton, stealth molecule. Curr Opin Cell Biol 12: 581–586. - PubMed
1. Lomako J, Lomako WM, Whelan WJ. 2004. Glycogenin: The primer for mammalian and yeast glycogen synthesis. Biochim Biophys Acta 1673: 45–55. - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
- NCBI Bookshelf

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Nucleocytoplasmic Glycosylation

Book Affiliations

Nucleocytoplasmic Glycosylation

Authors

Book Editors

Book Affiliations

Excerpt

Sections

References

Publication types

LinkOut - more resources

Full Text Sources