Review

N-Glycans

Pamela Stanley, Naoyuki Taniguchi, Markus Aebi

, editors.

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 9.

2017.

Affiliations

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876855
Bookshelf ID: NBK453020
DOI: 10.1101/glycobiology.3e.009

Free Books & Documents

Review

N-Glycans

Pamela Stanley et al.

Free Books & Documents

In: Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015. Chapter 9.

2017.

Authors

Pamela Stanley, Naoyuki Taniguchi, Markus Aebi

Book Editors

Book Affiliations

¹ Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
² Professor of Surgery, Director, National Center for Functional Glycomics, Harvard Medical School, Cambridge, Massachusetts, USA
³ Distinguished Professor of Cellular & Molecular Medicine, Co-Director, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California, USA
⁴ Horace W. Goldsmith Foundation Chair and Professor of Cell Biology, Albert Einstein College of Medicine, New York, New York, USA
⁵ Professor and Chairman of Biological Chemistry, Johns Hopkins University, Baltimore, Maryland, USA
⁶ Professor of Mycology, ETH Zürich, Zürich, Switzerland
⁷ Regents Professor and Director, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, USA
⁸ Professor, Laboratory of Immunoglycobiology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
⁹ Professor of Glycoproteomics and Glycomics, Macquarie University and Institute for Glycomics, Griffith University, Sydney, Australia
¹⁰ Professor and Eminent Scholar, University of Georgia, Athens, Georgia, USA
¹¹ Professor, Departments of Pharmacology and Neuroscience, Johns Hopkins University, Baltimore, Maryland, USA
¹² Director, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

PMID: 28876855
Bookshelf ID: NBK453020
DOI: 10.1101/glycobiology.3e.009

Excerpt

N-Glycans are covalently attached to protein at asparagine (Asn) residues by an N-glycosidic bond. Although diverse sugars are attached to Asn in prokaryotes (Chapters 21 and 22), all eukaryotic N-glycans begin with GlcNAcβ1–Asn and are the focus of this chapter. The biosynthesis of N-glycans is most complex in mammals and is described here in detail. Terminal sugars that largely determine the diversity of N-glycans are described in Chapter 14. Glycosylation-mediated quality control of protein folding by N-glycans is presented in Chapter 39, and the mannose-6-phosphate recognition determinant on N-glycans, necessary for targeting lysosomal hydrolases to lysosomes, is described in Chapter 33. Human congenital disorders of glycosylation arising from defects in N-glycan synthesis are discussed in Chapter 45.

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References

1. Waechter CJ, Lennarz WJ. 1976. The role of polyprenol-linked sugars in glycoprotein synthesis. Annu Rev Biochem 45: 95–112. - PubMed
1. Snider MD, Sultzman LA, Robbins PW. 1980. Transmembrane location of oligosaccharide-lipid synthesis in microsomal vesicles. Cell 21: 385–392. - PubMed
1. Kornfeld R, Kornfeld S. 1985. Assembly of asparagine-linked oligosaccharides. Annu Rev Biochem 54: 631–664. - PubMed
1. Herscovics A. 1999. Importance of glycosidases in mammalian glycoprotein biosynthesis. Biochim Biophys Acta 1473: 96–107. - PubMed
1. Berninsone PM, Hirschberg CB. 2000. Nucleotide sugar transporters of the Golgi apparatus. Curr Opin Struct Biol 10: 542–547. - PubMed

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N-Glycans

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N-Glycans

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