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. 2018 Mar;57(3):503-506.
doi: 10.1002/mus.25955. Epub 2017 Oct 6.

An instrumented timed up and go in facioscapulohumeral muscular dystrophy

Jessie Huisinga  1 , Adam Bruetsch  1 , Ayla Mccalley  2 , Melissa Currence  2 , Laura Herbelin  2 , Omar Jawdat  2 , Mamatha Pasnoor  2 , Mazen Dimachkie  2 , Richard Barohn  2 , Jeffrey Statland  2
Affiliations

An instrumented timed up and go in facioscapulohumeral muscular dystrophy

Jessie Huisinga et al. Muscle Nerve. 2018 Mar.

Abstract

Introduction: Instrumenting timed functional motor tasks may reveal a continuum of motor disability that predicts future motor dysfunction.

Methods: We performed a prospective study of the instrumented timed up and go (iTUG) test in genetically confirmed facioscapulohumeral muscular dystrophy (FSHD) participants using a commercially available system of wireless motion sensors. Patients returned within 2 weeks to determine test-retest reliability. Gait parameters in FSHD participants were compared with a normative database, FSHD clinical severity score, manual muscle testing, and patient-reported functional disability.

Results: Gait parameters in FSHD participants were significantly (P < 0.05) altered compared with normative values, and reliability was excellent (intraclass correlation coefficient 0.84-0.99). Stride velocity and trunk sagittal range of motion had moderate to strong correlations to other FSHD disease measures.

Discussion: The iTUG was reliable, abnormal in FSHD, and could distinguish between participants with differing disease severities. Instrumenting timed functional tasks may prove to be useful in FSHD clinical trials. Muscle Nerve 57: 503-506, 2018.

Keywords: PROMIS PF; facioscapulohumeral muscular dystrophy; iTUG; test-retest reliability; timed up and go test.

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Conflict of interest statement

Conflicts of Interest: J. Statland is a consultant for Acceleron, aTyr, Regeneron, and Strongbridge. All other authors report no disclosures.

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